IQP - University of Gothenburg

Integrated Quantitative Pharmacology:

Concepts and Applications (15 ECTS)

Sep 1 - Nov 7, 2008


There is a tremendous demand for PK and PK/PD trained analysts within Academia, Industry and Regulatory Agencies as well as for researchers and analysts with in-depth knowledge in Integrated Pharmacology. There is also a costly time-lag from the Industry’s need of this competence and request for new courses, to the final output of competent scientists. The gap between need and what is provided by educational institutions is continuously growing. Since there are very little formal academic training programs on the Master level within Europe in this field, this advanced course is aimed to bridge some of that gap. The programme is aimed to give the participant a sense that when he/she is entering the scientific area, this is knowledge that has immediate bearings on the drug discovery-development process. The course provides an interface between the computer analysis of PK and PD data and physiological concepts. Based on the background and concepts provided by the course lecturers, delegates will apply this information to the WinNonlin industry standard modeling package. A unique feature of the course is the access to the computer package to undertake hands-on exercises on real-life case studies and availability of course tutors to help in problem solving. The participants will be exposed to a wide range of real life preclinical and clinical PK/PD datasets based on single/multiple subjects. There will be a 2-day introductory PK/PD module starting at the beginning of the main programme.


COURSE TEAM

Assistant Professor Gunnar Tobin
is a teacher at the Department of Pharmacology, University of Gothenburg. He has experience from research at the academia, industry and regulatory affairs at medical product agencies.
  Professor Johan Gabrielsson
is a Senior Principal Scientist at AstraZeneca R&D Mölndal. He is academically affiliated as Adjunct Professor at the Department of Pharmacology, University of Gothenburg.



OUTLINE PROGRAMME

•   Basic pharmacodynamic theory
•   Turnover concept and modelling
•   Effect compartment models
•   Receptor on/off binding models
•   Pharmacodynamic complexities
•   Single/multiple dose dynamics
•   Inter-species scaling of PD data
•   Tolerance & rebound models
•   Transduction, synergy
•   PKPD in discov & development
•   Antibody/protein/peptide PKPD
•   Pharmacological targets
•   Receptor systems
•   Receptor binding models
•   Tachyphylaxis
•   Calculations in receptor pharmacology
•   Ion channel pharmacology
•   Transporters
•   Enzyme pharmacology
•   Special transmitter systems
•   Translation medicine
•   Immunopharmacology



AIM

This unique programme in Quantitative Pharmacology provides an interface between the computer analysis of PK & PD data and physiological concepts. Based on the background and concepts provided by the course lecturers, delegates will apply this information to the appropriate modelling package (WinNonlin) in hands-on exercises on real-life case studies.


WHO SHOULD ATTEND?

Biochemists, DMPK, pharmacology, clinical pharmacology and toxicology scientists, and researchers with a working knowledge of Quantitative Pharmacology who want to learn more about the advanced features of the subject.


ENTRANCE REQUIREMENTS

Degree of Bachelor in Biomedicine/Chemistry or equivalent subject (180 scp) and relevant work experience in biochemistry, pharmacology, clinical pharmacology, or toxicology.


COURSE OUTLINE

Morning sessions consist of lectures dealing with e.g. receptor pharmacology and pharmacodynamic theory, interpretation of computer output, practical experimental design, discrimination between rival models and combining data from different sources. Afternoon/evening sessions are devoted to applying the methods discussed in the lectures to actual data.

An extensive number of pharmacodynamic models and real life data sets will be covered. The course is given in English, and consists of several major and minor modules:


MODULES

Module A: Pharmacology;
              module A1: General Quantitative Pharmacology (1.5 ECTS)
              module A2: Specialized Quantitative Pharmacology

Module B: PK/PD;
              module B1: PK/PD (3 ECTS)
              module B2: Advanced Pharmacokinetics
              module B3: Integrated PK/PD

Module C: Specialized Topics;
              module C1: Introductory PK/PD
              module C2: Pharmacology in the Future

Module D: Individual Project Work





* * * HOW TO APPLY * * *
Evaluation of qualifications as well as official acceptance decisions will be undertaken by the Course Team at the Department of Pharmacology, Institute of Neuroscience and Physiology, Gothenburg University. Academic degrees, geographical distibution, practical work experience etc will be factors of importance for this process.


COURSE ADMINISTRATION


Questions to:

Course Administrator Patrik Aronsson

E-mail: patrik.aronsson@pharm.gu.se

Phone: + 46 - 31 - 786 3440

FAX: + 46 - 31 - 82 10 85

Postal Address:
Department of Pharmacology
University of Gothenburg
Box 431
SE 405 30 Gothenburg
Sweden


COURSE MATERIAL


The delegate pack, which is provided at the start of the workshop, includes copies of all presentation material, group exercises, project exercise, and reference list.


MANDATORY COURSE LITERATURE:

1.) - The 4th edition of “Pharmacokinetic/Pharmacodynamic Data Analysis:
Concepts and Applications”
(Swedish Pharmaceutical Press 2006, 1250 pages)
.


2.) - Textbook of Receptor Pharmacology, Second Edition,
edited by by John C. Foreman and Torben Johansen,
(CRC Press 2002, 289 pages)







GOTHENBURG:

INFORMATION ABOUT THE CITY, ACCOMODATIONS ETC

- Official Guide for the City and the Region Göteborg Plus

- City of Göteborg

- CityGuide-Europe: Göteborg

- Hotell Web





SWEDEN
AND
STUDYING IN SWEDEN:

- Everything about Sweden: "SWEDEN.SE"

- Study in Sweden

- Do I need a visa or residence permit?

- Accommodation

- New application procedure for master's programs in Sweden

- Applying (general information)



- "Preparation" - useful info for foreign students from the University of Gothenburg (visa, living, insurances etc)





UNIVERSITY OF GOTHENBURG:

- Main page

- The Sahlgrenska Academy

- The Institute of Neuroscience and Pharmacology

- Department of Pharmacology




  This interactive map shows the location of the Medical School ("Medicinsk Högskola") where IQP will take place.
- You can navigate the map by mouse dragging, and zoom in/out by clicking on the numbered squares in the zooming application in the lower left corner.




AstraZeneca







OTHER MASTER COURSES


Alternative courses at Master level can be found at
Göteborg International Bioscience Business School